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Andrea Manni Selected Research

Eflornithine (Ornidyl)

11/2008Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
1/2008Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
1/2008Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
11/2007Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
9/2007Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
12/2005Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
1/2005Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
1/2005Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
1/2005Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
1/2004Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
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Andrea Manni Research Topics

Disease

32Breast Neoplasms (Breast Cancer)
12/2021 - 01/2002
22Neoplasms (Cancer)
12/2021 - 01/2002
10Carcinogenesis
12/2017 - 03/2010
8Neoplasm Metastasis (Metastasis)
08/2015 - 01/2003
3Inflammation (Inflammations)
01/2019 - 08/2012
2Hyperparathyroidism
04/2020 - 07/2011
2Obesity
12/2017 - 04/2016
2Carcinoma (Carcinomatosis)
03/2015 - 08/2012
1Sarcopenia
04/2022
1Renal Insufficiency (Renal Failure)
04/2020
1Parathyroid Neoplasms (Parathyroid Neoplasm)
04/2020
1Cardiovascular Diseases (Cardiovascular Disease)
01/2020
1Chronic Disease (Chronic Diseases)
01/2020
1Weight Loss (Weight Reduction)
12/2017
1Hyperthyroidism
04/2015
1Pancreatitis
04/2015
1Pancreatic Neoplasms (Pancreatic Cancer)
03/2015
1Prostatic Neoplasms (Prostate Cancer)
04/2014
1Osteoporosis
07/2013
1Cushing Syndrome
03/2010
1Gastrinoma
11/2007
1Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2007

Drug/Important Bio-Agent (IBA)

13Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
12/2021 - 03/2010
13PolyaminesIBA
11/2008 - 01/2002
11Eflornithine (Ornidyl)FDA Link
11/2008 - 01/2003
9Fish OilsIBA
01/2020 - 03/2010
9TamoxifenFDA LinkGeneric
04/2016 - 03/2010
7Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
11/2008 - 01/2002
6Proteins (Proteins, Gene)FDA Link
12/2021 - 12/2005
6Biomarkers (Surrogate Marker)IBA
12/2017 - 11/2011
6Biological ProductsIBA
05/2016 - 01/2004
6Hormones (Hormone)IBA
01/2015 - 12/2004
5Docosahexaenoic AcidsIBA
12/2021 - 02/2015
5EnzymesIBA
11/2008 - 01/2002
4Fatty Acids (Saturated Fatty Acids)IBA
12/2017 - 08/2012
4Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
01/2012 - 03/2010
34-oxo-5,7,10,13,16,19-docosahexaenoic acidIBA
12/2021 - 02/2015
3Raloxifene Hydrochloride (Evista)FDA Link
04/2016 - 07/2013
3Estrogen Receptor Modulators (Antiestrogen)IBA
04/2016 - 03/2010
3Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA
09/2013 - 10/2011
2GelsolinIBA
01/2019 - 09/2013
2LipidsIBA
05/2016 - 08/2012
2Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2015 - 03/2010
2Estrogen ReceptorsIBA
01/2015 - 08/2011
2Dietary Fats (Dietary Fat)IBA
01/2012 - 10/2011
2Caspase 3 (Caspase-3)IBA
01/2008 - 09/2007
1EndocannabinoidsIBA
12/2021
1Antineoplastic Agents (Antineoplastics)IBA
11/2021
115-hydroxyprostaglandin dehydrogenaseIBA
11/2021
1Lipoxygenase (Lipoxygenase-1)IBA
11/2021
1Dinoprostone (PGE2)FDA Link
11/2021
1DenosumabFDA Link
04/2020
1Cinacalcet (Sensipar)FDA Link
04/2020
1Parathyroid Hormone (Parathormone)IBA
04/2020
1AcidsIBA
05/2016
1docosahexaenoylascorbic acid (DHA-As)IBA
05/2016
1Ether (Diethyl Ether)IBA
05/2016
1Liposomes (Liposome)IBA
05/2016
1OmacorFDA Link
04/2016
1Indicators and Reagents (Reagents)IBA
08/2015
1Lipase (Acid Lipase)FDA Link
04/2015
1Methimazole (Thiamazole)FDA LinkGeneric
04/2015
1Propranolol (Inderal)FDA LinkGeneric
04/2015
1CeramidesIBA
03/2015
1Small Interfering RNA (siRNA)IBA
03/2015
1Proteasome Endopeptidase Complex (Proteasome)IBA
03/2015
1Phenobarbital (Luminal)FDA Link
02/2015
1CytokinesIBA
01/2015
1Phospholipids (Phosphatides)FDA LinkGeneric
04/2014
1Vitamin D-Binding ProteinIBA
09/2013
1Selective Estrogen Receptor Modulators (SERM)IBA
07/2013
1Apoptotic Protease-Activating Factor 1IBA
08/2012
1Messenger RNA (mRNA)IBA
01/2012
1gamma-Synuclein (Persyn)IBA
01/2012
1RNA (Ribonucleic Acid)IBA
01/2012
1Estrogens (Estrogen)FDA Link
11/2011
1Insulin-Like Growth Factor I (IGF-1)IBA
10/2011
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
08/2011
1Corn Oil (Oil, Corn)IBA
08/2011
1Dihydrotachysterol (AT 10)IBA
07/2011
1Dexamethasone (Maxidex)FDA LinkGeneric
03/2010
1PPAR gammaIBA
03/2010
1LigandsIBA
03/2010
1AntioxidantsIBA
03/2010
1Glutathione (Reduced Glutathione)IBA
03/2010
1Phosphotransferases (Kinase)IBA
11/2008
1tyrosine receptor (receptor, tyrosine)IBA
11/2008
1Carrier Proteins (Binding Protein)IBA
01/2008
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
01/2008
1Monoclonal AntibodiesIBA
11/2007
1Pantoprazole (Protonix)FDA LinkGeneric
11/2007
1Serotonin (5 Hydroxytryptamine)IBA
11/2007
1Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
11/2007
1GastrinsIBA
11/2007
1Extracellular Matrix ProteinsIBA
11/2007

Therapy/Procedure

5Therapeutics
01/2008 - 11/2002
3Chemoprevention
01/2015 - 11/2002
1Wearable Electronic Devices
04/2022
1Metastasectomy
04/2020
1Secondary Prevention
01/2020